Research, analysis, and regulatory intelligence.

Is Holistic Medicine the Right Choice for Your Rare Disease?

Exploring holistic and complementary approaches to rare disease care, including nutritional therapy, mind-body practices, and integrative medicine, while emphasizing the importance of working with your medical team.

December 15, 2025

How Personalized Medicine is Changing the Rare Disease Journey

Personalized medicine is transforming rare disease care by using genetic information to tailor treatments and shorten the diagnostic odyssey from years to days.

December 1, 2025

Can the C2S-Scale AI Find New Treatments for Rare Disease Patients?

Exploring C2S-Scale, a new AI framework developed by researchers at Yale and Google that decodes cellular patterns to accelerate drug discovery for rare diseases.

November 15, 2025

How to Prioritize Mental Health While Living with a Rare Disease

Understanding the deep connection between chronic illness and mental health, and practical strategies for managing emotional well-being while living with a rare disease.

How SHEPHERD AI is Guiding Rare Disease Patients to Faster Answers

SHEPHERD is an innovative AI framework that learns from simulated patient data and biomedical knowledge maps to accelerate rare disease diagnosis while protecting patient privacy.

How Drug Repurposing Is Changing Rare Disease Treatment

Drug repurposing offers a faster, more affordable path to treatments for rare diseases by finding new uses for existing approved medications, accelerated by artificial intelligence.

Understanding Inflammation in Rare Diseases

A deep dive into how chronic inflammation drives many rare diseases, from autoimmune mechanisms to cytokine signaling, and practical strategies for managing the inflammatory journey.

Choosing the Right Community Platform: A Guide for Rare Disease Patient Advocacy Groups

A comprehensive guide for rare disease patient advocacy groups evaluating digital community platforms, comparing health networks, social media, infrastructure tools, and patient-first alternatives.

July 23, 2025

More Human, Not Less: Our Approach to Using AI for the March Forward Podcast

A transparent look at how March uses AI as a tool to enhance, not replace, the human process behind the March Forward podcast -- from research to medical review to production.

July 18, 2025

A Journey into the Cell: Understanding LSDs and Enzyme Replacement Therapy

Understanding Lysosomal Storage Diseases and how Enzyme Replacement Therapy works to supply the missing enzymes, along with its important benefits and limitations.

A Living Medicine: A New Chapter for Synovial Sarcoma

Exploring Tecelra (afamitresgene autoleucel), the first T-cell receptor therapy approved for a solid tumor, and what it means for the synovial sarcoma community.

A New Horizon for Hemophilia B: Understanding the Journey of Gene Therapy

Understanding how gene therapy is transforming Hemophilia B treatment, from the science of viral vector delivery to the real-world challenges of bringing these therapies to patients.

A Targeted Step Forward: Understanding WHIM Syndrome and a New Therapy

Exploring the science behind WHIM syndrome and the breakthrough FDA-approved therapy mavorixafor (XOLREMDI), the first treatment to target the root cause of this ultra-rare immune disorder.

Targeting Rare Diseases: The Power of In Vivo Base Editing

Understanding in vivo base editing, a groundbreaking gene editing technology that works like a molecular pencil to correct single DNA errors directly inside the body.

Event

Beyond "Rare": Rethinking the Diagnostic Odyssey at our GenAI x Rare Disease Event

Dr. Laurel Crosby Delof from Stanford proposes reframing rare diseases as "Obscuropathies" -- solvable mysteries rather than inherently rare phenomena -- and outlines a data-driven framework for accelerating diagnosis.

May 21, 2025

Getting to Know Dr. Sadaf Ashtari and Her 15-Year Journey to Rare Disease Diagnosis

Dr. Sadaf Ashtari shares her 15-year diagnostic odyssey with Ehlers-Danlos Syndrome and how her personal experience inspired research into building better patient communities.

May 21, 2025

Event

When Passion Meets Possibility: Insights from March's AI x Rare Disease Event

Highlights from March's GenAI x Rare Disease event at UC Berkeley, featuring David Apple's journey from tech executive to biotech founder and an expert panel on AI's role in rare disease diagnosis and treatment.

May 21, 2025